IZIIS has four laboratories, namely, a dynamic testing laboratory, a geophysical laboratory, a soil dynamics laboratory, and a strong motion laboratory.

The work of IZIIS is divided into five departments: Natural and Technological Hazards and Ecology, Building Structures and Material: Design, Analysis and Testing, Engineering Structures, the Department on Risk, Disaster Management and Strategic Planning (RDM/IZIIS), the Department for Geotechnics and Special Structures, and the Dynamic Testing Laboratory and Informatics (Dynlab&Info).

Some of the equipment that can be found in the Institute are shaking tables, material testing frames, quasi-static equipment, equipment for specialised field measurements in engeneering seismology, a dynamic simple shear apparatus, a cyclic triaxial system and ambient and force vibrations.

The Institute has participated in many important projects, which have been already concluded or are still ongoing, such as e.g. in proof tests on a shaking table of a new brick laying system, in shaking table testing of Wienerberger unreinforced masonry models, or in the determination of the seismic potential of a site.

In addition to direct cooperation of the Institute with universities, institutions and the economic sector of the country, within the framework of the above mentioned activities a permanent and intensive international cooperation has been developed and maintained. Such international cooperation with universities, scientific institutions and centres worldwide is a prerequisite for more efficient and more complex scientific research within the Institute.